As human factors specialists working at the intersection of human performance and nuclear operations, we are witnessing one of the nuclear sector’s most significant transitions in decades. The emergence of small modular reactors, microreactors, and other advanced designs is reshaping the industry’s landscape. Digital instrumentation and controls, passive safety systems, and increased automation are creating opportunities for greater safety margins and more flexible operation. These same features also fundamentally redefine what it means to “operate” a nuclear plant. Interactions among human roles, automation, and passive systems shape how people maintain awareness, exercise judgment, and intervene when necessary. These developments affect both operational realities and the regulatory foundations on which nuclear safety is built.